Terminalia albida treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti-inflammatory properties
Identifieur interne : 000066 ( France/Analysis ); précédent : 000065; suivant : 000067Terminalia albida treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti-inflammatory properties
Auteurs : Aissata Camara [France, Guinée] ; Mohamed Haddad [France] ; Karine Reybier [France] ; Mohamed Sahar Traoré [Guinée] ; Mamadou Aliou Baldé [Guinée] ; Jade Royo [France] ; Alpha Omar Baldé [Guinée] ; Philippe Batigne [France] ; Mahamane Haidara [Mali] ; Elhadj Saidou Baldé [Guinée] ; Agnès Coste [France] ; Aliou Mamadou Baldé [Guinée] ; Agnès Aubouy [France]Source :
- Malaria Journal [ 1475-2875 ] ; 2019.
Abstract
The development of
In vitro antiplasmodial activity was evaluated on a chloroquine-resistant strain of
In vitro antiplasmodial activity of
The traditional use of
Url:
DOI: 10.1186/s12936-019-3071-9
PubMed: 31852507
PubMed Central: 6921526
Affiliations:
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PMC:6921526Le document en format XML
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wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Traore, Mohamed Sahar" sort="Traore, Mohamed Sahar" uniqKey="Traore M" first="Mohamed Sahar" last="Traoré">Mohamed Sahar Traoré</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka</wicri:regionArea><wicri:noRegion>Dubréka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea><wicri:noRegion>Conakry</wicri:noRegion></affiliation></author><author><name sortKey="Balde, Mamadou Aliou" sort="Balde, Mamadou Aliou" uniqKey="Balde M" first="Mamadou Aliou" last="Baldé">Mamadou Aliou Baldé</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka</wicri:regionArea><wicri:noRegion>Dubréka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea><wicri:noRegion>Conakry</wicri:noRegion></affiliation></author><author><name sortKey="Royo, Jade" sort="Royo, Jade" uniqKey="Royo J" first="Jade" last="Royo">Jade Royo</name><affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Balde, Alpha Omar" sort="Balde, Alpha Omar" uniqKey="Balde A" first="Alpha Omar" last="Baldé">Alpha Omar Baldé</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka</wicri:regionArea><wicri:noRegion>Dubréka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea><wicri:noRegion>Conakry</wicri:noRegion></affiliation></author><author><name sortKey="Batigne, Philippe" sort="Batigne, Philippe" uniqKey="Batigne P" first="Philippe" last="Batigne">Philippe Batigne</name><affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Haidara, Mahamane" sort="Haidara, Mahamane" uniqKey="Haidara M" first="Mahamane" last="Haidara">Mahamane Haidara</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0567 336X</institution-id><institution-id institution-id-type="GRID">grid.461088.3</institution-id><institution>Department of Pharmacy,</institution><institution>University of Sciences, Technics and Technologies (USTTB) of Bamako,</institution></institution-wrap>Bamako, Mali</nlm:aff><country xml:lang="fr">Mali</country><wicri:regionArea>Bamako</wicri:regionArea></affiliation></author><author><name sortKey="Balde, Elhadj Saidou" sort="Balde, Elhadj Saidou" uniqKey="Balde E" first="Elhadj Saidou" last="Baldé">Elhadj Saidou Baldé</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka</wicri:regionArea><wicri:noRegion>Dubréka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea><wicri:noRegion>Conakry</wicri:noRegion></affiliation></author><author><name sortKey="Coste, Agnes" sort="Coste, Agnes" uniqKey="Coste A" first="Agnès" last="Coste">Agnès Coste</name><affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Balde, Aliou Mamadou" sort="Balde, Aliou Mamadou" uniqKey="Balde A" first="Aliou Mamadou" last="Baldé">Aliou Mamadou Baldé</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea><wicri:noRegion>Conakry</wicri:noRegion></affiliation></author><author><name sortKey="Aubouy, Agnes" sort="Aubouy, Agnes" uniqKey="Aubouy A" first="Agnès" last="Aubouy">Agnès Aubouy</name><affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31852507</idno><idno type="pmc">6921526</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921526</idno><idno type="RBID">PMC:6921526</idno><idno type="doi">10.1186/s12936-019-3071-9</idno><date 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reactive oxygen species scavenging and anti-inflammatory properties</title><author><name sortKey="Camara, Aissata" sort="Camara, Aissata" uniqKey="Camara A" first="Aissata" last="Camara">Aissata Camara</name><affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka</wicri:regionArea><wicri:noRegion>Dubréka</wicri:noRegion></affiliation></author><author><name sortKey="Haddad, Mohamed" sort="Haddad, Mohamed" uniqKey="Haddad M" first="Mohamed" last="Haddad">Mohamed Haddad</name><affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Reybier, Karine" sort="Reybier, Karine" uniqKey="Reybier K" first="Karine" last="Reybier">Karine Reybier</name><affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Traore, Mohamed Sahar" sort="Traore, Mohamed Sahar" uniqKey="Traore M" first="Mohamed Sahar" last="Traoré">Mohamed Sahar Traoré</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka</wicri:regionArea><wicri:noRegion>Dubréka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea><wicri:noRegion>Conakry</wicri:noRegion></affiliation></author><author><name sortKey="Balde, Mamadou Aliou" sort="Balde, Mamadou Aliou" uniqKey="Balde M" first="Mamadou Aliou" last="Baldé">Mamadou Aliou Baldé</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka</wicri:regionArea><wicri:noRegion>Dubréka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea><wicri:noRegion>Conakry</wicri:noRegion></affiliation></author><author><name sortKey="Royo, Jade" sort="Royo, Jade" uniqKey="Royo J" first="Jade" last="Royo">Jade Royo</name><affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Balde, Alpha Omar" sort="Balde, Alpha Omar" uniqKey="Balde A" first="Alpha Omar" last="Baldé">Alpha Omar Baldé</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka</wicri:regionArea><wicri:noRegion>Dubréka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea><wicri:noRegion>Conakry</wicri:noRegion></affiliation></author><author><name sortKey="Batigne, Philippe" sort="Batigne, Philippe" uniqKey="Batigne P" first="Philippe" last="Batigne">Philippe Batigne</name><affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Haidara, Mahamane" sort="Haidara, Mahamane" uniqKey="Haidara M" first="Mahamane" last="Haidara">Mahamane Haidara</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0567 336X</institution-id><institution-id institution-id-type="GRID">grid.461088.3</institution-id><institution>Department of Pharmacy,</institution><institution>University of Sciences, Technics and Technologies (USTTB) of Bamako,</institution></institution-wrap>Bamako, Mali</nlm:aff><country xml:lang="fr">Mali</country><wicri:regionArea>Bamako</wicri:regionArea></affiliation></author><author><name sortKey="Balde, Elhadj Saidou" sort="Balde, Elhadj Saidou" uniqKey="Balde E" first="Elhadj Saidou" last="Baldé">Elhadj Saidou Baldé</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka</wicri:regionArea><wicri:noRegion>Dubréka</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea><wicri:noRegion>Conakry</wicri:noRegion></affiliation></author><author><name sortKey="Coste, Agnes" sort="Coste, Agnes" uniqKey="Coste A" first="Agnès" last="Coste">Agnès Coste</name><affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Balde, Aliou Mamadou" sort="Balde, Aliou Mamadou" uniqKey="Balde A" first="Aliou Mamadou" last="Baldé">Aliou Mamadou Baldé</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff><country xml:lang="fr">Guinée</country><wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea><wicri:noRegion>Conakry</wicri:noRegion></affiliation></author><author><name sortKey="Aubouy, Agnes" sort="Aubouy, Agnes" uniqKey="Aubouy A" first="Agnès" last="Aubouy">Agnès Aubouy</name><affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author></analytic><series><title level="j">Malaria Journal</title><idno type="eISSN">1475-2875</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">The development of <italic>Plasmodium</italic> resistance to the last effective anti-malarial drugs necessitates the urgent development of new anti-malarial therapeutic strategies. To this end, plants are an important source of new molecules. The objective of this study was to evaluate the anti-malarial effects of <italic>Terminalia albida</italic>, a plant used in Guinean traditional medicine, as well as its anti-inflammatory and antioxidant properties, which may be useful in treating cases of severe malaria.</p></sec><sec><title>Methods</title><p id="Par2">In vitro antiplasmodial activity was evaluated on a chloroquine-resistant strain of <italic>Plasmodium falciparum</italic> (K-1). In vivo efficacy of the plant extract was measured in the experimental cerebral malaria model based on <italic>Plasmodium berghei</italic> (strain ANKA) infection. Mice brains were harvested on Day 7–8 post-infection, and T cells recruitment to the brain, expression levels of pro- and anti-inflammatory markers were measured by flow cytometry, RT-qPCR and ELISA. Non-malarial in vitro models of inflammation and oxidative response were used to confirm <italic>Terminalia albida</italic> effects. Constituents of <italic>Terminalia albida</italic> extract were characterized by ultra‐high performance liquid chromatography coupled with high resolution mass spectrometry. Top ranked compounds were putatively identified using plant databases and in silico fragmentation patterns.</p></sec><sec><title>Results</title><p id="Par3">In vitro antiplasmodial activity of <italic>Terminalia albida</italic> was confirmed with an IC50 of 1.5 μg/mL. In vivo, <italic>Terminalia albida</italic> treatment greatly increased survival rates in <italic>P. berghei</italic>-infected mice. Treated mice were all alive until Day 12, and the survival rate was 50% on Day 20. <italic>Terminalia albida</italic> treatment also significantly decreased parasitaemia by 100% on Day 4 and 89% on Day 7 post-infection. In vivo anti-malarial activity was related to anti-inflammatory properties, as <italic>Terminalia albida</italic> treatment decreased T lymphocyte recruitment and expression of pro-inflammatory markers in brains of treated mice. These properties were confirmed in vitro in the non-malarial model. In vitro, <italic>Terminalia albida</italic> also demonstrated a remarkable dose-dependent neutralization activity of reactive oxygen species. Twelve compounds were putatively identified in <italic>Terminalia albida</italic> stem bark. Among them, several molecules already identified may be responsible for the different biological activities observed, especially tannins and triterpenoids.</p></sec><sec><title>Conclusion</title><p id="Par4">The traditional use of <italic>Terminalia albida</italic> in the treatment of malaria was validated through the combination of in vitro and in vivo studies.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ashley, Ea" uniqKey="Ashley E">EA Ashley</name></author><author><name sortKey="Dhorda, M" uniqKey="Dhorda M">M Dhorda</name></author><author><name sortKey="Fairhurst, Rm" uniqKey="Fairhurst R">RM Fairhurst</name></author><author><name sortKey="Amaratunga, C" uniqKey="Amaratunga C">C Amaratunga</name></author><author><name sortKey="Lim, P" uniqKey="Lim P">P Lim</name></author><author><name sortKey="Suon, S" uniqKey="Suon S">S 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Carretero, A" uniqKey="Segura Carretero A">A Segura-Carretero</name></author><author><name sortKey="Utrilla, Mp" uniqKey="Utrilla M">MP Utrilla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Araujo, A" uniqKey="De Araujo A">A de Araújo</name></author><author><name sortKey="Iles, B" uniqKey="Iles B">B Iles</name></author><author><name sortKey="De Nogueira, K" uniqKey="De Nogueira K">K de Nogueira</name></author><author><name sortKey="Dias, J" uniqKey="Dias J">J Dias</name></author><author><name sortKey="Placido, A" uniqKey="Placido A">A Plácido</name></author><author><name sortKey="Rodrigues, A" uniqKey="Rodrigues A">A Rodrigues</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manosroi, A" uniqKey="Manosroi A">A Manosroi</name></author><author><name sortKey="Jantrawut, P" uniqKey="Jantrawut P">P Jantrawut</name></author><author><name sortKey="Ogihara, E" uniqKey="Ogihara E">E Ogihara</name></author><author><name sortKey="Yamamoto, A" uniqKey="Yamamoto A">A Yamamoto</name></author><author><name sortKey="Fukatsu, M" uniqKey="Fukatsu M">M Fukatsu</name></author><author><name sortKey="Yasukawa, K" uniqKey="Yasukawa K">K Yasukawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeb, A" uniqKey="Zeb A">A Zeb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Shitany, Na" uniqKey="El Shitany N">NA El-Shitany</name></author><author><name sortKey="El Bastawissy, Ea" uniqKey="El Bastawissy E">EA El-Bastawissy</name></author><author><name sortKey="El Desoky, K" uniqKey="El Desoky K">K El-desoky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name></author><author><name sortKey="Zhang, Sl" uniqKey="Zhang S">SL Zhang</name></author><author><name sortKey="Tao, Jy" uniqKey="Tao J">JY Tao</name></author><author><name sortKey="Pang, R" uniqKey="Pang R">R Pang</name></author><author><name sortKey="Jin, F" uniqKey="Jin F">F Jin</name></author><author><name sortKey="Guo, Yj" uniqKey="Guo Y">YJ Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, Xr" uniqKey="Dong X">XR Dong</name></author><author><name sortKey="Luo, M" uniqKey="Luo M">M Luo</name></author><author><name sortKey="Fan, L" uniqKey="Fan L">L Fan</name></author><author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author><author><name sortKey="Dong, Jh" uniqKey="Dong J">JH Dong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, H R" uniqKey="Li H">H-R Li</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Zhang, S L" uniqKey="Zhang S">S-L Zhang</name></author><author><name sortKey="Luo, T" uniqKey="Luo T">T Luo</name></author><author><name sortKey="Wu, F" uniqKey="Wu F">F Wu</name></author><author><name sortKey="Dong, J H" uniqKey="Dong J">J-H Dong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, M C" uniqKey="Kim M">M-C Kim</name></author><author><name sortKey="Kim, S J" uniqKey="Kim S">S-J Kim</name></author><author><name sortKey="Kim, D S" uniqKey="Kim D">D-S Kim</name></author><author><name sortKey="Jeon, Y D" uniqKey="Jeon Y">Y-D Jeon</name></author><author><name sortKey="Park, Sj" uniqKey="Park S">SJ Park</name></author><author><name sortKey="Lee, Hs" uniqKey="Lee H">HS Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calixto Campos, C" uniqKey="Calixto Campos C">C Calixto-Campos</name></author><author><name sortKey="Carvalho, Tt" uniqKey="Carvalho T">TT Carvalho</name></author><author><name sortKey="Hohmann, Msn" uniqKey="Hohmann M">MSN Hohmann</name></author><author><name sortKey="Pinho Ribeiro, Fa" uniqKey="Pinho Ribeiro F">FA Pinho-Ribeiro</name></author><author><name sortKey="Fattori, V" uniqKey="Fattori V">V Fattori</name></author><author><name sortKey="Manchope, Mf" uniqKey="Manchope M">MF Manchope</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yadav, Vr" uniqKey="Yadav V">VR Yadav</name></author><author><name sortKey="Prasad, S" uniqKey="Prasad S">S Prasad</name></author><author><name sortKey="Sung, B" uniqKey="Sung B">B Sung</name></author><author><name sortKey="Kannappan, R" uniqKey="Kannappan R">R Kannappan</name></author><author><name sortKey="Aggarwal, Bb" uniqKey="Aggarwal B">BB Aggarwal</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Guinée</li><li>Mali</li></country><region><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li></region><settlement><li>Toulouse</li></settlement></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Camara, Aissata" sort="Camara, Aissata" uniqKey="Camara A" first="Aissata" last="Camara">Aissata Camara</name></region><name sortKey="Aubouy, Agnes" sort="Aubouy, Agnes" uniqKey="Aubouy A" first="Agnès" last="Aubouy">Agnès Aubouy</name><name sortKey="Batigne, Philippe" sort="Batigne, Philippe" uniqKey="Batigne P" first="Philippe" last="Batigne">Philippe Batigne</name><name sortKey="Coste, Agnes" sort="Coste, Agnes" uniqKey="Coste A" first="Agnès" last="Coste">Agnès Coste</name><name sortKey="Haddad, Mohamed" sort="Haddad, Mohamed" uniqKey="Haddad M" first="Mohamed" last="Haddad">Mohamed Haddad</name><name sortKey="Reybier, Karine" sort="Reybier, Karine" uniqKey="Reybier K" first="Karine" last="Reybier">Karine Reybier</name><name sortKey="Royo, Jade" sort="Royo, Jade" uniqKey="Royo J" first="Jade" last="Royo">Jade Royo</name></country><country name="Guinée"><noRegion><name sortKey="Camara, Aissata" sort="Camara, Aissata" uniqKey="Camara A" first="Aissata" last="Camara">Aissata Camara</name></noRegion><name sortKey="Balde, Aliou Mamadou" sort="Balde, Aliou Mamadou" uniqKey="Balde A" first="Aliou Mamadou" last="Baldé">Aliou Mamadou Baldé</name><name sortKey="Balde, Alpha Omar" sort="Balde, Alpha Omar" uniqKey="Balde A" first="Alpha Omar" last="Baldé">Alpha Omar Baldé</name><name sortKey="Balde, Alpha Omar" sort="Balde, Alpha Omar" uniqKey="Balde A" first="Alpha Omar" last="Baldé">Alpha Omar Baldé</name><name sortKey="Balde, Elhadj Saidou" sort="Balde, Elhadj Saidou" uniqKey="Balde E" first="Elhadj Saidou" last="Baldé">Elhadj Saidou Baldé</name><name sortKey="Balde, Elhadj Saidou" sort="Balde, Elhadj Saidou" uniqKey="Balde E" first="Elhadj Saidou" last="Baldé">Elhadj Saidou Baldé</name><name sortKey="Balde, Mamadou Aliou" sort="Balde, Mamadou Aliou" uniqKey="Balde M" first="Mamadou Aliou" last="Baldé">Mamadou Aliou Baldé</name><name sortKey="Balde, Mamadou Aliou" sort="Balde, Mamadou Aliou" uniqKey="Balde M" first="Mamadou Aliou" last="Baldé">Mamadou Aliou Baldé</name><name sortKey="Traore, Mohamed Sahar" sort="Traore, Mohamed Sahar" uniqKey="Traore M" first="Mohamed Sahar" last="Traoré">Mohamed Sahar Traoré</name><name sortKey="Traore, Mohamed Sahar" sort="Traore, Mohamed Sahar" uniqKey="Traore M" first="Mohamed Sahar" last="Traoré">Mohamed Sahar Traoré</name></country><country name="Mali"><noRegion><name sortKey="Haidara, Mahamane" sort="Haidara, Mahamane" uniqKey="Haidara M" first="Mahamane" last="Haidara">Mahamane Haidara</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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